Novel Hexahydrospiro[piperidine-4,1‘-pyrrolo[3,4-c]pyrroles]: Highly Selective Small-Molecule Nociceptin/Orphanin FQ Receptor Agonists-Reference-Cited by-同舟云学术

Novel Hexahydrospiro[piperidine-4,1‘-pyrrolo[3,4-c]pyrroles]: Highly Selective Small-Molecule Nociceptin/Orphanin FQ Receptor Agonists

Published:2002-12-11 Issue:2 Volume:46 Page:255-264
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kolczewski Sabine¹,Adam Geo¹,Cesura Andrea M.¹,Jenck François¹,Hennig Michael¹,Oberhauser Thomas¹,Poli Sonia M.¹,Rössler Felix¹,Röver Stephan¹,Wichmann Jürgen¹,Dautzenberg Frank M.¹

Affiliation:

1. Pharma Division, Preclinical Research, F. Hoffmann-La Roche Ltd., Grenzacher Strasse 124, CH-4070 Basel, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0209174

Reference23 articles.

1. Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor

2. Negative regulation of T-cell adhesion and activation by CD43

3. ORL1, a novel member of the opioid receptor family

4. Modulation of Voltage-Gated Calcium Channels by Orphanin FQ in Freshly Dissociated Hippocampal Neurons

5. Increase by the ORL1 receptor (opioid receptor-like1) ligand, nociceptin, of inwardly rectifying K conductance in dorsal raphe nucleus neurones

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