Design, Synthesis, and Biological Evaluation of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Evaluation of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors

Published:2007-12-12 Issue:1 Volume:51 Page:68-76
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gangjee Aleem¹,Li Wei¹,Yang Jie¹,Kisliuk Roy L.¹

Affiliation:

1. Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, Pennsylvania 15282, and Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm701052u

Reference48 articles.

1. Towards Species-specific Antifolates

2. Dihydrofolate reductase inhibitors as antibacterial agents

3. Novel Chemical Strategies for Thymidylate Synthase Inhibition

4. Thymidylate synthase: a critical target in cancer therapy?

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