Uncovering the Metabolic Origin of Aspartate for Tumor Growth Using an Integrated Molecular Deactivator

Author:

Duan Ruixue1,Xu Yuanyuan23,Zeng Xuemei4,Xu Jiahui1,Liang Liangliang1ORCID,Zhang Zhenzhen5,Wang Zhimin6,Jiang Xiaoxiao7,Xing Bengang6ORCID,Liu Bifeng4,All Angelo8,Li Xiaosong23,Lee Luke P.91011ORCID,Liu Xiaogang11112ORCID

Affiliation:

1. Department of Chemistry, National University of Singapore, Singapore 117543

2. Department of Oncology, The Fourth Medical Center of Chinese People’s Liberation Army General Hospital, Beijing 100048, China

3. Jinzhou Medical University, Jinzhou 121001, China

4. Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China

5. Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou 510631, China

6. Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore 637371

7. Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China

8. Department of Chemistry, Hong Kong Baptist University, 224 Waterloo Road, Kowloon Tong, Hong Kong SAR, China

9. Berkeley Sensor and Actuator Centre, Department of Bioengineering, Department of Electrical Engineering and Computer Science, and Biophysics Graduate Program, University of California at Berkeley, Berkeley, California 94720, United States

10. Department of Medicine, Harvard Medical School, Brigham and Women Hospital, Boston, Massachusetts 02115, United States

11. Biomedical Institute of Global Healthcare Research and Technology (BIGHEART), National University of Singapore, Singapore 117456

12. The N.1 Institute for Health, National University of Singapore, Singapore 117456

Funder

Agency for Science, Technology and Research

Ministry of Science and Technology of the People's Republic of China

Ministry of Education - Singapore

National Research Foundation Singapore

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Mechanical Engineering,Condensed Matter Physics,General Materials Science,General Chemistry,Bioengineering

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