Aspartate is an endogenous metabolic limitation for tumour growth
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology
Link
http://www.nature.com/articles/s41556-018-0125-0.pdf
Reference33 articles.
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3. Gui, D. Y. et al. Environment dictates dependence on mitochondrial complex I for NAD+ and aspartate production and determines cancer cell sensitivity to metformin. Cell Metab. 24, 716–727 (2016).
4. Birsoy, K. et al. An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis. Cell 162, 540–551 (2015).
5. Schalk, A. M., Nguyen, H.-A., Rigouin, C. & Lavie, A. Identification and structural analysis of an l-asparaginase enzyme from guinea pig with putative tumor cell killing properties. J. Biol. Chem. 289, 33175–33186 (2014).
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