Selective Single-Molecule Nanopore Detection of mpox A29 Protein Directly in Biofluids

Author:

Cai Shenglin1,Ren Ren123ORCID,He Jiaxuan4,Wang Xiaoyi1,Zhang Zheng4,Luo Zhaofeng4ORCID,Tan Weihong4ORCID,Korchev Yuri23,Edel Joshua B.1ORCID,Ivanov Aleksandar P.1ORCID

Affiliation:

1. Department of Chemistry, Imperial College London, Molecular Science Research Hub, White City Campus, 82 Wood Lane, London W12 0BZ, U.K.

2. Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Campus, Du Cane Road, London W12 0NN, U.K.

3. Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan

4. The Key Laboratory of Zhejiang Province for Aptamers and Theranostics, Aptamer Selection Center, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, People’s Republic of China

Funder

Engineering and Physical Sciences Research Council

Ministry of Education, Culture, Sports, Science and Technology

Royal Society of Chemistry

Japan Society for the Promotion of Science

National Natural Science Foundation of China

H2020 European Research Council

Biotechnology and Biological Sciences Research Council

Natural Science Foundation of Zhejiang Province

Zhejiang Provincial Research Center for Diagnosis and Treatment of Major Diseases

Zhejiang Province

Publisher

American Chemical Society (ACS)

Subject

Mechanical Engineering,Condensed Matter Physics,General Materials Science,General Chemistry,Bioengineering

Reference57 articles.

1. Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus

2. Centers for Disease Control and Prevention. 2022–2023 Mpox Outbreak Global Map. https://www.cdc.gov/poxvirus/monkeypox/response/2022/world-map.html (accessed September 13, 2023).

3. World Health Organization. WHO Director-General declares the ongoing monkeypox outbreak a Public Health Emergency of International Concern. https://www.who.int/europe/news/item/23-07-2022-who-director-general-declares-the-ongoing-monkeypox-outbreak-a-public-health-event-of-international-concern (accessed 23 July, 2022).

4. World Health Organization. Monkeypox fact sheet. https://www.who.int/news-room/fact-sheets/detail/monkeypox (accessed April 18, 2023).

5. Don’t forget about human factors: Lessons learned from COVID-19 point-of-care testing

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