Identification, Synthesis, and Biological Evaluation of Metabolites of the Experimental Cancer Treatment Drugs Indotecan (LMP400) and Indimitecan (LMP776) and Investigation of Isomerically Hydroxylated Indenoisoquinoline Analogues as Topoisomerase I Poisons-Reference-Cited by-同舟云学术

Identification, Synthesis, and Biological Evaluation of Metabolites of the Experimental Cancer Treatment Drugs Indotecan (LMP400) and Indimitecan (LMP776) and Investigation of Isomerically Hydroxylated Indenoisoquinoline Analogues as Topoisomerase I Poisons

Published:2012-12-07 Issue:24 Volume:55 Page:10844-10862
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cinelli Maris A.¹,Reddy P. V. Narasimha¹,Lv Peng-Cheng¹,Liang Jian-Hua¹,Chen Lian²,Agama Keli³,Pommier Yves³,van Breemen Richard B.²,Cushman Mark¹

Affiliation:

1. Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy, and the Purdue Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, United States

2. Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The University of Illinois at Chicago, Chicago, Illinois 60612, United States

3. Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892-4255, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300519w

Reference69 articles.

1. Topoisomerase I inhibitors: camptothecins and beyond

2. A Model for the Mechanism of Human Topoisomerase I

3. Cellular roles of DNA topoisomerases: a molecular perspective

4. DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition

5. Repair of Topoisomerase I‐Mediated DNA Damage

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