Discovery of 2-{3-[2-(1-Isopropyl-3-methyl-1H-1,2–4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): A β-Sparing Phosphoinositide 3-Kinase Inhibitor with High Unbound Exposure and Robust in Vivo Antitumor Activity-Reference-Cited by-同舟云学术

Discovery of 2-{3-[2-(1-Isopropyl-3-methyl-1H-1,2–4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): A β-Sparing Phosphoinositide 3-Kinase Inhibitor with High Unbound Exposure and Robust in Vivo Antitumor Activity

Published:2013-06-03 Issue:11 Volume:56 Page:4597-4610
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ndubaku Chudi O.,Heffron Timothy P.,Staben Steven T.,Baumgardner Matthew,Blaquiere Nicole,Bradley Erin,Bull Richard¹,Do Steven,Dotson Jennafer,Dudley Danette,Edgar Kyle A.,Friedman Lori S.,Goldsmith Richard,Heald Robert A.¹,Kolesnikov Aleksandr,Lee Leslie,Lewis Cristina,Nannini Michelle,Nonomiya Jim,Pang Jodie,Price Steve¹,Prior Wei Wei,Salphati Laurent,Sideris Steve,Wallin Jeffery J.,Wang Lan,Wei BinQing,Sampath Deepak,Olivero Alan G.

Affiliation:

1. Argenta Discovery, 8-9 Spire Green Centre, Flex Meadow, Harlow, Essex, CM19 5TR, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm4003632

Reference24 articles.

1. The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

2. The Phosphoinositide 3-Kinase Pathway

3. Mutation of the PIK3CA Gene in Ovarian and Breast Cancer