Structural Basis for Isoform Selectivity in a Class of Benzothiazole Inhibitors of Phosphoinositide 3-Kinase γ-Reference-Cited by-同舟云学术

Structural Basis for Isoform Selectivity in a Class of Benzothiazole Inhibitors of Phosphoinositide 3-Kinase γ

Published:2014-05-02 Issue:1 Volume:58 Page:517-521
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Collier Philip N.¹,Martinez-Botella Gabriel¹,Cornebise Mark¹,Cottrell Kevin M.¹,Doran John D.¹,Griffith James P.¹,Mahajan Sudipta¹,Maltais François¹,Moody Cameron S.¹,Huck Emilie Porter¹,Wang Tiansheng¹,Aronov Alex M.¹

Affiliation:

1. Vertex Pharmaceuticals Inc., 50 Northern Avenue, Boston, Massachusetts 02210, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500362j

Reference27 articles.

1. The emerging mechanisms of isoform-specific PI3K signalling

2. The Phosphoinositide 3-Kinase Pathway

3. Signalling through Class I PI3Ks in mammalian cells

4. Small Molecule Inhibitors of Phosphoinositide 3-Kinase (PI3K) δ and γ

5. Phosphoinositide 3-Kinase γ Is an Essential Amplifier of Mast Cell Function

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