Genomics-Guided Discovery of Thailanstatins A, B, and C As Pre-mRNA Splicing Inhibitors and Antiproliferative Agents from Burkholderia thailandensis MSMB43

Author:

Liu Xiangyang12,Biswas Sreya1,Berg Michael G.3,Antapli Christopher M.1,Xie Feng4,Wang Qi4,Tang Man-Cheng5,Tang Gong-Li5,Zhang Lixin4,Dreyfuss Gideon3,Cheng Yi-Qiang12

Affiliation:

1. Department of Biological Sciences and Department of Chemistry and Biochemistry, University of Wisconsin−Milwaukee, Milwaukee, Wisconsin 53201, United States

2. UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, Texas 76107, United States

3. Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, United States

4. CAS Key Laboratory of Pathogenic Microbiology & Immunology, Institute of Microbiology, Chinese Academy of Sciences (CAS), Beijing 100190, People’s Republic of China

5. State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, People’s Republic of China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

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