Expansion of the eukaryotic proteome by alternative splicing
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/nature08909.pdf
Reference84 articles.
1. Alt, F. W. et al. Synthesis of secreted and membrane-bound immunoglobulin μ heavy chains is directed by mRNAs that differ at their 3′ ends. Cell 20, 293–301 (1980).
2. Early, P. et al. Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathways. Cell 20, 313–319 (1980).
3. Rosenfeld, M. G. et al. Calcitonin mRNA polymorphism: peptide switching associated with alternative RNA splicing events. Proc. Natl Acad. Sci. USA 79, 1717–1721 (1982).
4. Pan, Q., Shai, O., Lee, L. J., Frey, B. J. & Blencowe, B. J. Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nature Genet. 40, 1413–1415 (2008).
5. Wang, E. T. et al. Alternative isoform regulation in human tissue transcriptomes. Nature 456, 470–476 (2008). References 4 and 5 provide detailed views of the human transcriptome as determined by using deep-sequencing data. The authors conclude that the pre-mRNAs from all multi-exon genes are alternatively spliced.
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