Functionally Important Conformations of the Met20 Loop in Dihydrofolate Reductase are Populated by Rapid Thermal Fluctuations
Author:
Affiliation:
1. Department of Chemistry and Biophysics Program, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109
Publisher
American Chemical Society (ACS)
Subject
Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis
Link
https://pubs.acs.org/doi/pdf/10.1021/ja9000135
Reference53 articles.
1. In search of dihydrofolate reductase
2. Blakely, R. L.InChemistry and Biochemistry of Folates. In folates and pterins;Blakely, R. L. and Benkovic, S. J., Eds.Wiley:New York, 1984; Vol.3, pp191−253.
3. Protein Dynamics in Enzymatic Catalysis: Exploration of Dihydrofolate Reductase
4. Network of coupled promoting motions in enzyme catalysis
5. How Dihydrofolate Reductase Facilitates Protonation of Dihydrofolate
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