1. Biomolecular Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, SW7 2AZ, U.K., Bristol Myers-Squibb, Route 206 and Province Line Road, Princeton, New Jersey 08543-4000, Drug Safety Research and Development, Pfizer Global Research and Development, Chazy, New York 12921, and Waters Corporation, 34 Maple Street, Milford, Massachusetts 01757