The Effect of MSTN Mutation on Bile Acid Metabolism and Lipid Metabolism in Cattle

Author:

Wu Di1ORCID,Wang Song12,Hai Chao1,Wang Linfeng1,Pei Dongchao1,Bai Chunling1,Su Guanghua1,Liu Xuefei1,Zhao Yuefang1,Liu Zhonghua2ORCID,Yang Lei1,Li Guangpeng1

Affiliation:

1. State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Science, Inner Mongolia University, Hohhot 010021, China

2. College of Life Science, Northeast Agricultural University, Harbin 150030, China

Abstract

Myostatin (MSTN) is a negative regulator of skeletal muscle genesis during development. MSTN mutation leads to increased lean meat production and reduced fat deposition in livestock. However, the mechanism by which MSTN promotes myogenesis by regulating metabolism is not clear. In this study, we compared the metabolomics of the livers of wild-type (WT) and MSTN mutation cattle (MT), and found changes in the content and proportion of fatty acids and bile acids in MT cattle. The differential metabolites were enriched in sterol synthesis and primary bile acid synthesis. We further analyzed the expression of genes involved in the regulation of lipid and bile acid metabolism, and found that the loss of MSTN may alter lipid synthesis and bile acid metabolism. This study provides new basic data for MSTN mutations in beef cattle breeding.

Funder

Inner Mongolia Autonomous Region Open Competition Projects

Inner Mongolia Autonomous Region Science and Technology Major Project

Inner Mongolia Autonomous Region Science and Technology Leading Team

Inner Mongolia Autonomous Region Young Talents Support Project

Central Government Guides Local Science and Technology Development Funds

Inner Mongolia Autonomous Region High-Level Talent Support Program

Inner Mongolia University Chief Scientist Program

Publisher

MDPI AG

Subject

Molecular Biology,Biochemistry,Endocrinology, Diabetes and Metabolism

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