Using Ovality to Predict Nonmutagenic, Orally Efficacious Pyridazine Amides as Cell Specific Spleen Tyrosine Kinase Inhibitors-Reference-Cited by-同舟云学术

Using Ovality to Predict Nonmutagenic, Orally Efficacious Pyridazine Amides as Cell Specific Spleen Tyrosine Kinase Inhibitors

Published:2014-02-26 Issue:6 Volume:57 Page:2683-2691
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Lucas Matthew C.¹,Bhagirath Niala¹,Chiao Eric¹,Goldstein David M.¹,Hermann Johannes C.¹,Hsu Pei-Yuan¹,Kirchner Stephan²,Kennedy-Smith Joshua J.¹,Kuglstatter Andreas¹,Lukacs Christine¹,Menke John¹,Niu Linghao¹,Padilla Fernando¹,Peng Ying¹,Polonchuk Liudmila²,Railkar Aruna¹,Slade Michelle¹,Soth Michael¹,Xu Daigen¹,Yadava Preeti¹,Yee Calvin¹,Zhou Mingyan¹,Liao Cheng¹

Affiliation:

1. Hoffmann-La Roche Inc., pRED, Pharma Research & Early Development, Small Molecule Research, 340 Kingsland Street, Nutley, New Jersey 07110, United States

2. Hoffmann-La Roche Inc., pRED, Pharma Research & Early Development, Small Molecule Research, Grenzacherstrasse 124, 4070 Basle, Switzerland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401982j

Reference23 articles.

1. The SYK tyrosine kinase: a crucial player in diverse biological functions

2. Spleen tyrosine kinase: a novel target for therapeutic intervention of rheumatoid arthritis

3. Syk, c-Src, the αvβ3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption

4. Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

5. Fostamatinib disodium

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