Discovery of 3-(1H-benzo[d]imidazole-2-yl)-1H-pyrazol-4 -amine derivatives as novel and potent syk inhibitors for the treatment of hematological malignancies

Author:

Cui Bingbing,Wang Yong,Zhao Zhipeng,Fan Lu,Jiao Yu,Li Hongmei,Feng Jie,Tang Weifang,Lu Tao,Chen YadongORCID

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Pharmacology,General Medicine

Reference37 articles.

1. The SYK tyrosine kinase: a crucial player in diverse biological functions;Mocsai;Nat. Rev. Immunol.,2010

2. Targeting the SYK-BTK axis for the treatment of immunological and hematological disorders: recent progress and therapeutic perspectives;Tan;Pharmacol. Therapeut.,2013

3. Spleen tyrosine kinases: biology, therapeutic targets and drugs;Mauro Riccaboni;Drug Discov. Today.,2010

4. Autoinhibition and adapter function of Syk;Kulathu;Immunol. Rev.,2010

5. The tyrosine kinase network regulating mast cell activation;Gilfillan;Immunol. Rev.,2009

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