β-Methyl Substitution of Cyclohexylalanine in Dmt-Tic-Cha-Phe Peptides Results in Highly Potent δ Opioid Antagonists-Reference-Cited by-同舟云学术

β-Methyl Substitution of Cyclohexylalanine in Dmt-Tic-Cha-Phe Peptides Results in Highly Potent δ Opioid Antagonists

Published:2006-12-21 Issue:2 Volume:50 Page:328-333
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tóth Géza¹,Ioja Enikő¹,Tömböly Csaba¹,Ballet Steven¹,Tourwé Dirk¹,Péter Antal¹,Martinek Tamás¹,Chung Nga N.¹,Schiller Peter W.¹,Benyhe Sándor¹,Borsodi Anna¹

Affiliation:

1. Institute of Biochemistry, Biological Research Center, Hungarian Academy of Sciences, Post Office Box 521 H-6701 Szeged, Hungary, Department of Organic Chemistry, Vrije Universiteit Brussel, B-1050 Brussels, Belgium, Department of Inorganic and Analytical Chemistry, University of Szeged, Post Office Box 440, Szeged, Hungary, Institute of Pharmaceutical Chemistry, University of Szeged, Post Office Box 121 H-6701 Szeged, Hungary, and Clinical Research Institute of Montreal, Montreal, Quebec, H2W 1R7 Canada

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060721u

Reference34 articles.

1. Differential stereochemical requirements of mu vs. delta opioid receptors for ligand binding and signal transduction: development of a class of potent and highly delta-selective peptide antagonists.

2. TIPP[.psi.]: a highly potent and stable pseudopeptide .delta. opioid receptor antagonist with extraordinary .delta. selectivity

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