1. Drug Discovery and Design Centre, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China, Department of Medicinal Chemistry, China Pharmaceutical University, 24 TongjiaXiang, Nanjing 210009, China, and School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China