Long-Lived States in Hyperpolarized Deuterated Methyl Groups Reveal Weak Binding of Small Molecules to Proteins-Reference-Cited by-同舟云学术

Long-Lived States in Hyperpolarized Deuterated Methyl Groups Reveal Weak Binding of Small Molecules to Proteins

Published:2019-03-13 Issue:7 Volume:10 Page:1523-1529
ISSN:1948-7185
Container-title:The Journal of Physical Chemistry Letters
language:en
Short-container-title:J. Phys. Chem. Lett.

Author:

Kress Thomas¹²^ORCID,Walrant Astrid³^ORCID,Bodenhausen Geoffrey¹,Kurzbach Dennis²^ORCID

Affiliation:

1. Laboratoire des Biomolécules, LBM, Département de Chimie, École Normale Supérieure, PSL University, Sorbonne Université, CNRS, 75005 Paris, France

2. Faculty of Chemistry, Institute of Biological Chemistry, University of Vienna, Währinger Strasse 38, 1090 Vienna, Austria

3. Laboratoire des Biomolécules, LBM, École Normale Supérieure, Sorbonne Université, École Normale Supérieure, PSL University, CNRS, 75005 Paris, France

Funder

Centre National de la Recherche Scientifique

H2020 European Research Council

FP7 Ideas: European Research Council

Publisher

American Chemical Society (ACS)

Subject

General Materials Science,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jpclett.9b00149

Reference34 articles.

1. Expression, purification, assay, and crystal structure of perdeuterated human arginase I

2. Using Deuterium in Drug Discovery: Leaving the Label in the Drug

3. A Randomized Phase I Evaluation of CTP-499, a Novel Deuterium-Containing Drug Candidate for Diabetic Nephropathy

4. Altering Metabolic Profiles of Drugs by Precision Deuteration: Reducing Mechanism-Based Inhibition of CYP2D6 by Paroxetine

5. Hyperpolarization of Deuterated Metabolites via Remote Cross-Polarization and Dissolution Dynamic Nuclear Polarization

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