In Vitro Bioactivation of a Selective Estrogen Receptor Modulator (2S,3R)-(+)-3-(3-Hydroxyphenyl)-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol (I) in Liver Microsomes: Formation of Adenine Adducts-Reference-Cited by-同舟云学术

In Vitro Bioactivation of a Selective Estrogen Receptor Modulator (2S,3R)-(+)-3-(3-Hydroxyphenyl)-2-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-2,3-dihydro-1,4-benzoxathiin-6-ol (I) in Liver Microsomes: Formation of Adenine Adducts

Published:2012-10-09 Issue:11 Volume:25 Page:2368-2377
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Li Ying¹,Doss George A.¹,Li Yan¹,Chen Qing¹,Tang Wei¹,Zhang Zhoupeng¹

Affiliation:

1. Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx3002466

Reference28 articles.

1. Drug−Protein Adducts: An Industry Perspective on Minimizing the Potential for Drug Bioactivation in Drug Discovery and Development

2. Metabolism and Toxicity of Drugs. Two Decades of Progress in Industrial Drug Metabolism

3. Addressing Metabolic Activation as an Integral Component of Drug Design

4. Applying Mechanisms of Chemical Toxicity to Predict Drug Safety

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