3,3-Dialkyl- and 3-Alkyl-3-Benzyl-Substituted 2-Pyrrolidinones: A New Class of Anticonvulsant Agents-Reference-Cited by-同舟云学术

3,3-Dialkyl- and 3-Alkyl-3-Benzyl-Substituted 2-Pyrrolidinones: A New Class of Anticonvulsant Agents

Published:1996-01-01 Issue:9 Volume:39 Page:1898-1906
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Reddy P. Amruta¹,Hsiang Bonnie C. H.¹,Latifi Tammy N.¹,Hill Matthew W.¹,Woodward Karen E.¹,Rothman Steven M.¹,Ferrendelli James A.¹,Covey Douglas F.¹

Affiliation:

1. Departments of Molecular Biology and Pharmacology, Anatomy and Neurobiology, Neurology and Neurosurgery, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63110, and Division of Pediatric Neurology, St. Louis Children's Hospital, One Children's Place, St. Louis, Missouri 63110, and Department of Neurology, University of Texas Health Science Center, 6431 Fannin Street, Houston, Texas 77030

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9600196

Reference47 articles.

1. Alpha-Substituted γ-Butyrolactones: New Class of Anticonvulsant Drugs

2. .alpha.-Spirocyclopentyl- and .alpha.-spirocyclopropyl-.gamma.-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant .alpha.,.alpha.-disubstituted .gamma.-butyrolactones

3. Synthesis and structure-activity studies of alkyl-substituted .gamma.-butyrolactones and .gamma.-thiobutyrolactones: ligands for the picrotoxin receptor

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