Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates and Diphosphates: A Potential Route to New Bone Antiresorption and Antiparasitic Agents-Reference-Cited by-同舟云学术

Inhibition of Geranylgeranyl Diphosphate Synthase by Bisphosphonates and Diphosphates: A Potential Route to New Bone Antiresorption and Antiparasitic Agents

Published:2002-04-20 Issue:11 Volume:45 Page:2185-2196
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Szabo Christina M.¹,Matsumura Yoshihiro¹,Fukura Sayaka¹,Martin Michael B.¹,Sanders John M.¹,Sengupta Suraj¹,Cieslak John A.¹,Loftus Timothy C.¹,Lea Christopher R.¹,Lee Hyung-Jae¹,Koohang Ali¹,Coates Robert M.¹,Sagami Hiroshi¹,Oldfield Eric¹

Affiliation:

1. Department of Chemistry, University of Illinois at Urbana−Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, and Institute of Multidisciplinary Research for Advanced Materials, Tohoku University, Katahira 2-1-1, Aoba-ku, Sendai 980-8577, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm010412y

Reference42 articles.

1. Maximizing the Cost-effectiveness of Lipid-Lowering Therapy

2. Nitrogen-Containing Bisphosphonates as Carbocation Transition State Analogs for Isoprenoid Biosynthesis

3. The Discovery of a Novel Site of Action for Herbicidal Bisphosphonates

4. Mechanism of Aminobisphosphonate Action: Characterization of Alendronate Inhibition of the Isoprenoid Pathway

5. Alendronate Is a Specific, Nanomolar Inhibitor of Farnesyl Diphosphate Synthase

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