Novel Benzimidazole Inhibitors Bind to a Unique Site in the Kinesin Spindle Protein Motor Domain-Reference-Cited by-同舟云学术

Novel Benzimidazole Inhibitors Bind to a Unique Site in the Kinesin Spindle Protein Motor Domain

Published:2010-09-03 Issue:38 Volume:49 Page:8350-8358
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Sheth Payal R.¹,Shipps Gerald W.²,Seghezzi Wolfgang³,Smith Catherine K.¹,Chuang Cheng-Chi¹,Sanden David³,Basso Andrea D.⁴,Vilenchik Lev¹,Gray Kimberly⁴,Annis D. Allen,Nickbarg Elliott⁵,Ma Yao²,Lahue Brian²,Herbst Ronald,Le Hung V.¹

Affiliation:

1. Protein Science Department

2. Lead Discovery Chemistry Department

3. Tumor Biology Department, Merck Research Laboratories, 901 California Avenue, Palo Alto, California 94304

4. Tumor Biology Department, Merck Research Laboratories, 3000 Galloping Hill Road, Kenilworth, New Jersey 07033

5. Biology Department

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi1005283

Reference31 articles.

1. Analysis of the kinesin superfamily: insights into structure and function

2. Microtubule motors in mitosis

3. To step or not to step? How biochemistry and mechanics influence processivity in Kinesin and Eg5

4. Mitotic Kinesins: Prospects for Antimitotic Drug Discovery

5. Inhibition of a Mitotic Motor Protein: Where, How, and Conformational Consequences

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