Exploring a potential allosteric inhibition mechanism in the motor domain of human Eg-5
Author:
Affiliation:
1. Department of Physiology & Pharmacology, Oregon Health Science University, Portland, OR, USA;
2. Department of BioMedical Sciences, Samuel Oschin Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Publisher
Informa UK Limited
Subject
Molecular Biology,General Medicine,Structural Biology
Link
https://www.tandfonline.com/doi/pdf/10.1080/07391102.2018.1486229
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1. Essential dynamics of proteins
2. Loop L5 Acts as a Conformational Latch in the Mitotic Kinesin Eg5
3. CHARMM: The biomolecular simulation program
4. Cryo-electron tomography of microtubule–kinesin motor complexes
5. Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2S)-4-(2,5-Difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer
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