Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2S)-4-(2,5-Difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer-Reference-Cited by-同舟云学术

Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2S)-4-(2,5-Difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer

Published:2008-06-25 Issue:14 Volume:51 Page:4239-4252
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cox Christopher D.¹,Coleman Paul J.¹,Breslin Michael J.¹,Whitman David B.¹,Garbaccio Robert M.¹,Fraley Mark E.¹,Buser Carolyn A.¹,Walsh Eileen S.¹,Hamilton Kelly¹,Schaber Michael D.¹,Lobell Robert B.¹,Tao Weikang¹,Davide Joseph P.¹,Diehl Ronald E.¹,Abrams Marc T.¹,South Vicki J.¹,Huber Hans E.¹,Torrent Maricel¹,Prueksaritanont Thomayant¹,Li Chunze¹,Slaughter Donald E.¹,Mahan Elizabeth¹,Fernandez-Metzler Carmen¹,Yan Youwei¹,Kuo Lawrence C.¹,Kohl Nancy E.¹,Hartman George D.¹

Affiliation:

1. Departments of Medicinal Chemistry, Cancer Research, Molecular Systems, Drug Metabolism, and Structural Biology, Merck Research Laboratories, P.O. Box 4, Sumneytown Pike, West Point, Pennsylvania 19486

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm800386y

Reference58 articles.

1. Chemotherapy and the war on cancer

2. Imatinib mesylate (Gleevec/Glivec) a molecular-targeted therapy for chronic myeloid leukaemia and other malignancies

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5. Sorafenib and Sunitinib: Novel Targeted Therapies for Renal Cell Cancer

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