New Associations between Drug-Induced Adverse Events in Animal Models and Humans Reveal Novel Candidate Safety Targets

Author:

Giblin Kathryn A.12ORCID,Basili Danilo1,Afzal Avid M.3,Rosenbrier-Ribeiro Lyn4,Greene Nigel5,Barrett Ian3,Hughes Samantha J.2,Bender Andreas1ORCID

Affiliation:

1. Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom

2. Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom

3. Data Sciences and Quantitative Biology, Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom

4. Safety Platforms, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom

5. Data Science and Artificial Intelligence, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Boston, Massachusetts 02451, United States

Funder

AstraZeneca

FP7 Ideas: European Research Council

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

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