Integrated In Silico Models for the Prediction of No-Observed-(Adverse)-Effect Levels and Lowest-Observed-(Adverse)-Effect Levels in Rats for Sub-chronic Repeated-Dose Toxicity

Author:

Gadaleta Domenico1ORCID,Marzo Marco1,Toropov Andrey1,Toropova Alla1ORCID,Lavado Giovanna J.1,Escher Sylvia E.2,Dorne Jean Lou C. M.3,Benfenati Emilio1ORCID

Affiliation:

1. Laboratory of Environmental Chemistry and Toxicology, Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy

2. Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), 30625 Hannover, Germany

3. Scientific Committee and Emerging Risks Unit, European Food Safety Authority, 43126 Parma, Italy

Funder

Horizon 2020 Framework Programme

European Food and Safety Authority

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Reference61 articles.

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4. Scientific Committee on Consumer Safety (SCCS) (2012) The SCCS’s notes of guidance for the testing of cosmetics substances and their safety evaluation, 8th revision, SCCS/1501/12,http://ec.europa.eu/health/scientific_committees/consumer_safety/docs/sccs_s_006.pdf (accessed June 2018).

5. Hazard Evaluation Support System (HESS) for predicting repeated dose toxicity using toxicological categories

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