N6-Formyllysine as a Biomarker of Formaldehyde Exposure: Formation and Loss of N6-Formyllysine in Nasal Epithelium in Long-Term, Low-Dose Inhalation Studies in Rats

Author:

Edrissi BaharORCID,Taghizadeh Koli,Moeller Benjamin C.12,Yu Rui1,Kracko Dean2,Doyle-Eisele Melanie2,Swenberg James A.1,Dedon Peter C.

Affiliation:

1. Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27514, United States

2. Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, United States

Funder

National Institute of Environmental Health Sciences

National Cancer Institute

Texas Commission on Environmental Quality

David H. Koch Cancer Research Fund, Massachusetts Institute of Technology

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Reference15 articles.

1. Formaldehyde Carcinogenicity Research

2. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans (2012) Chemical agents and related occupations.IARC monographs on the evaluation of carcinogenic risks to humans, Vol.100F, pp9–562, World Health Organization, International Agency for Research on Cancer.

3. Determination of N2-Hydroxymethyl-dG Adducts in the Nasal Epithelium and Bone Marrow of Nonhuman Primates Following 13CD2-Formaldehyde Inhalation Exposure

4. Formaldehyde and leukemia: Epidemiology, potential mechanisms, and implications for risk assessment

5. Endogenous Formaldehyde Is a Hematopoietic Stem Cell Genotoxin and Metabolic Carcinogen

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