Safety Lead Optimization and Candidate Identification: Integrating New Technologies into Decision-Making
Author:
Affiliation:
1. Department of Safety Assessment, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States
Funder
Genentech
Publisher
American Chemical Society (ACS)
Subject
Toxicology,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.5b00396
Reference171 articles.
1. Fit-for-Purpose Method Development and Validation for Successful Biomarker Measurement
2. Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development
3. The impact of assay technology as applied to safety assessment in reducing compound attrition in drug discovery
4. Exploratory toxicology as an integrated part of drug discovery. Part I: Why and how
5. Detection of viral RNA from paraffin-embedded tissues after prolonged formalin fixation
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