Reactive Metabolites: Current and Emerging Risk and Hazard Assessments-Reference-Cited by-同舟云学术

Reactive Metabolites: Current and Emerging Risk and Hazard Assessments

Published:2016-01-06 Issue:4 Volume:29 Page:505-533
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Thompson Richard A.¹,Isin Emre M.²,Ogese Monday O.³,Mettetal Jerome T.⁴,Williams Dominic P.³

Affiliation:

1. DMPK, Respiratory, Inflammation & Autoimmunity iMed, AstraZeneca R&D, 431 83 Mölndal, Sweden

2. DMPK, Cardiovascular & Metabolic Diseases iMed, AstraZeneca R&D, 431 83 Mölndal, Sweden

3. Translational Safety, Drug Safety and Metabolism, AstraZeneca R&D, Darwin Building 310, Cambridge Science Park, Milton Rd, Cambridge CB4 0FZ, United Kingdom

4. Translational Safety, Drug Safety and Metabolism, AstraZeneca R&D, 35 Gatehouse Dr, Waltham, Massachusetts 02451, United States

Funder

AstraZeneca

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.5b00410

Reference334 articles.

1. Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

2. Metabolites in Safety Testing: “MIST” for the Clinical Pharmacologist

3. Introduction: Human Metabolites in Safety Testing (MIST) Issue

4. Which Human Metabolites Have We MIST? Retrospective Analysis, Practical Aspects, and Perspectives For Metabolite Identification and Quantification in Pharmaceutical Development

5. From definition to implementation: a cross-industry perspective of past, current and future MIST strategies

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