Cytochromes P450 2C8 and 3A Catalyze the Metabolic Activation of the Tyrosine Kinase Inhibitor Masitinib-Reference-Cited by-同舟云学术

Cytochromes P450 2C8 and 3A Catalyze the Metabolic Activation of the Tyrosine Kinase Inhibitor Masitinib

Published:2022-09-01 Issue:9 Volume:35 Page:1467-1481
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Latham Bethany D.¹,Oskin D. Spencer²,Crouch Rachel D.²,Vergne Matthew J.²^ORCID,Jackson Klarissa D.¹^ORCID

Affiliation:

1. Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina at Chapel Hill Eshelman School of Pharmacy, Chapel Hill, North Carolina 27599, United States

2. Department of Pharmaceutical Sciences, Lipscomb University College of Pharmacy and Health Sciences, Nashville, Tennessee 37204, United States

Funder

College of Pharmacy and Health Sciences, Lipscomb University

National Institute of General Medical Sciences

UNC Eshelman School of Pharmacy

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.2c00057

Reference62 articles.

1. Masitinib (AB1010), a Potent and Selective Tyrosine Kinase Inhibitor Targeting KIT

2. Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

3. Masitinib as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomized clinical trial

4. Long-term survival analysis of masitinib in amyotrophic lateral sclerosis

5. Masitinib in advanced gastrointestinal stromal tumor (GIST) after failure of imatinib: A randomized controlled open-label trial

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