Toward Realistic Dosimetry <i>In Vitro</i>: Determining Effective Concentrations of Test Substances in Cell Culture and Their Prediction by an <i>In Silico</i> Mass Balance Model-Reference-Cited by-同舟云学术

Toward Realistic Dosimetry In Vitro: Determining Effective Concentrations of Test Substances in Cell Culture and Their Prediction by an In Silico Mass Balance Model

Published:2022-10-20 Issue:11 Volume:35 Page:1962-1973
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Dimitrijevic Dunja¹,Fabian Eric²,Nicol Beate³,Funk-Weyer Dorothee²,Landsiedel Robert¹²^ORCID

Affiliation:

1. Free University of Berlin, Institute of Pharmacy, Pharmacology and Toxicology, Königin-Luise-Straße 2−4, 14195Berlin, Germany

2. BASF SE, Experimental Toxicology and Ecology, Carl-Bosch-Straße 38, 67056Ludwigshafen am Rhein, Germany

3. Safety & Environmental Assurance Centre, Unilever U.K., Sharnbrook, MK44 ILQBedford, United Kingdom

Funder

BASF

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.2c00128

Reference72 articles.

1. Toward More Useful In Vitro Toxicity Data with Measured Free Concentrations

2. Insights into in vitro biokinetics using Virtual Cell Based Assay simulations

3. Quantitative in vitro to in vivo extrapolation (QIVIVE): An essential element for in vitro-based risk assessment

4. A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing

5. Quantification of freely dissolved effect concentrations in in vitro cell-based bioassays

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