Orlistat Displays Antitumor Activity and Enhances the Efficacy of Paclitaxel in Human Hepatoma Hep3B Cells
Author:
Affiliation:
1. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, China Medical University, Taichung 404, Taiwan
2. School of Pharmacy, China Medical University, Taichung 404, Taiwan
Funder
Ministry of Science and Technology, Taiwan
Publisher
American Chemical Society (ACS)
Subject
Toxicology,General Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.chemrestox.8b00269
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1. Orlistat Is a Novel Inhibitor of Fatty Acid Synthase with Antitumor Activity
2. Chemical inhibition of fatty acid synthase: molecular docking analysis and biochemical validation in ocular cancer cells
3. The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer
4. Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis
5. Inhibition of Fatty-acid Synthase Induces Caspase-8-mediated Tumor Cell Apoptosis by Up-regulating DDIT4
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