Neurosteroid Analogues. 9. Conformationally Constrained Pregnanes: Structure−Activity Studies of 13,24-Cyclo-18,21-dinorcholane Analogues of the GABA Modulatory and Anesthetic Steroids (3α,5α)- and (3α,5β)-3-Hydroxypregnan-20-one-Reference-Cited by-同舟云学术

Neurosteroid Analogues. 9. Conformationally Constrained Pregnanes: Structure−Activity Studies of 13,24-Cyclo-18,21-dinorcholane Analogues of the GABA Modulatory and Anesthetic Steroids (3α,5α)- and (3α,5β)-3-Hydroxypregnan-20-one

Published:2003-10-30 Issue:25 Volume:46 Page:5334-5348
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jiang Xin¹,Manion Brad D.¹,Benz Ann¹,Rath Nigam P.¹,Evers Alex S.¹,Zorumski Charles F.¹,Mennerick Steven¹,Covey Douglas F.¹

Affiliation:

1. Departments of Molecular Biology and Pharmacology, Anesthesiology, Psychiatry, and Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, Missouri 63110, and Department of Chemistry, University of Missouri−St. Louis, St. Louis, Missouri 63121

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm030302m

Reference24 articles.

1. Belelli, D.; Casula, A.; Ling, A.; Lambert, J. J. The Influence of Subunit Composition on the Interaction of Neurosteroids with GABAAReceptors.Neuropharmacol.2002,43, 651−661. (b) Lambert, J. J.; Belelli, D.; Harney, S. C.; Peters, J. A.; Frenguelli, B. G. Modulation of Native and Recombinant GABAAReceptors by Endogenous and Synthetic Neuroactive Steroids.Brain Res. Rev.2001,37, 68−80 2001. (c) Lambert, J. J.; Belelli, D.; Pistis, M.; Hill-Venning, C.; Peters, J. A.; The Interaction of Intravenous Anesthetic Agents with Native and Recombinant GABAAReceptors: An Electrophysiological Study. InGABA Receptors, 2nd ed.; Enna, S. A., Bowery, N. G., Eds.; Humana Press: Totowa, 1997; pp 121−156.

2. Neurosteroids: biochemistry and clinical significance

Cited by 32 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Role of Neuroactive Steroids in Analgesia and Anesthesia: An Interesting Comeback?;Biomolecules;2023-11-15

2. Preemptive Analgesic Effect of Intrathecal Applications of Neuroactive Steroids in a Rodent Model of Post-Surgical Pain: Evidence for the Role of T-Type Calcium Channels;Cells;2020-12-12

3. Novel d-Annulated Pentacyclic Steroids: Regioselective Synthesis and Biological Evaluation in Breast Cancer Cells;Molecules;2020-07-31

4. Neurosteroid Analogues. 18. Structure–Activity Studies of ent-Steroid Potentiators of γ-Aminobutyric Acid Type A Receptors and Comparison of Their Activities with Those of Alphaxalone and Allopregnanolone;Journal of Medicinal Chemistry;2013-12-24

5. The Knoevenagel reactions of pregnenolone with cyanomethylene reagents: Synthesis of thiophene, thieno[2,3-b]pyridine, thieno[3,2-d]isoxazole derivatives of pregnenolone and their in vitro cytotoxicity towards tumor and normal cell lines;Steroids;2013-12