The Knoevenagel reactions of pregnenolone with cyanomethylene reagents: Synthesis of thiophene, thieno[2,3-b]pyridine, thieno[3,2-d]isoxazole derivatives of pregnenolone and their in vitro cytotoxicity towards tumor and normal cell lines

Author:

Mohareb Rafat M.,El-Sayed Nahed N.E.,Abdelaziz Mahmoud A.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Pharmacology,Endocrinology,Molecular Biology,Biochemistry

Reference28 articles.

1. Covey DF, Jiang X. Preparation of GABA modulatory and anesthetic 24-cyclo-18,21-dinorcholanes and structurally related pentacyclic steroids. US Patent, 2004, p. 59.

2. Neurosteroid analogues. 9. Conformationally constrained pregnanes: structure–activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3,5)- and (3,5)-3-hydroxypregnan-20-one;Jiang;J Med Chem,2003

3. Synthesis of pentacyclic steroids;Ibrahim-Ouali;Steroids,2008

4. Microwave promoted one-pot synthesis of novel A-ring fused steroidal dehydropiperazines;Borthakur;Steroids,2008

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