A Practical Synthesis of the PDE4 Inhibitor, SB-207499, from a Cyclohexanone Precursor-Reference-Cited by-同舟云学术

A Practical Synthesis of the PDE4 Inhibitor, SB-207499, from a Cyclohexanone Precursor

Published:2002-10-30 Issue:1 Volume:7 Page:101-108
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Badham Neil F.¹,Chen Jian-Hao¹,Cummings Paul G.¹,Dell'Orco Philip C.¹,Diederich Ann M.¹,Eldridge Ann M.¹,Mendelson Wilford L.¹,Mills Robert J.¹,Novack Vance J.¹,Olsen Mark A.¹,Rustum Abu M.¹,Webb Kevin S.¹,Yang Shawn¹

Affiliation:

1. GlaxoSmithKline Pharmaceuticals, Department of Synthetic Chemistry, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, U.S.A., Department of Analytical Sciences, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, U.S.A., and Department of Environmental Research, 801 Riverside Road, King of Prussia, Pennsylvania 19406, U.S.A.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op025584z

Reference31 articles.

1. Cilomilast: a second generation phosphodiesterase 4 inhibitor for asthma and chronic obstructive pulmonary disease

2. 1,4-Cyclohexanecarboxylates: Potent and Selective Inhibitors of Phosophodiesterase 4 for the Treatment of Asthma

3. Wittig-type reactions of 2-lithio-2-trimethylsilyl-1,3-dithian: an improved and extended synthesis of alkylidenedithians for 1-carbon homologation

4. Urben, P. G., Ed.Bretherick's Handbook of Reactive ChemicalHazards, 5th ed.; Butterworth-Heinemann Ltd. Oxford, UK, 1995; Vol. 1, p 1246.

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