1. Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands, Department Infectious Diseases and Immunology, Division of Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands, Yamanouchi Europe BV, Leiderdorp, The Netherlands, and Members of UNYPHAR, a network collaboration between the universities of Groningen, Leiden, Utrecht, and the pharmaceutical company Yamanouchi