1. Early Lead Generation, Medicinal Chemistry Research, H. Lundbeck A/S, 9 Ottiliavej, DK-2500 Valby, Denmark, The Danish University of Pharmaceutical Science, 2 Universitetsparken, DK-2100 Copenhagen, Denmark, LifeCyclePharma, 4 Kogle Allé, DK-2970 Hoersholm, Denmark, and Center for Sustainable and Green Chemistry, Department of Chemistry, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark