Identification of N-Terminally Diversified GLP-1R Agonists Using Saturation Mutagenesis and Chemical Design

Author:

Longwell Chelsea K.1ORCID,Hanna Stephanie2,Hartrampf Nina23,Sperberg R. Andres Parra4,Huang Po-Ssu4,Pentelute Bradley L.2567ORCID,Cochran Jennifer R.48

Affiliation:

1. Department of Chemical and Systems Biology, Stanford University, 269 Campus Drive, Stanford, California 94305, United States

2. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

3. Department of Chemistry, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland

4. Department of Bioengineering, Stanford University, Shriram Center, 443 Via Ortega, Stanford, California 94305, United States

5. The Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02142, United States

6. Center for Environmental Health Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

7. Broad Institute of MIT and Harvard, 415 Main Street, Cambridge, Massachusetts 02142, United States

8. Department of Chemical Engineering, Stanford University, Shriram Center, 443 Via Ortega, Stanford, California 94305, United States

Funder

Novo Nordisk

U.S. Department of Commerce

Bristol-Myers Squibb

Stanford Diabetes Research Center

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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