Subsite Ligand Recognition and Cooperativity in the TPP Riboswitch: Implications for Fragment-Linking in RNA Ligand Discovery-Reference-Cited by-同舟云学术

Subsite Ligand Recognition and Cooperativity in the TPP Riboswitch: Implications for Fragment-Linking in RNA Ligand Discovery

Published:2022-01-21 Issue:2 Volume:17 Page:438-448
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Zeller Meredith J.¹,Nuthanakanti Ashok²,Li Kelin³,Aubé Jeffrey¹³,Serganov Alexander²,Weeks Kevin M.¹^ORCID

Affiliation:

1. Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, United States

2. Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, New York 10016, United States

3. Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7363, United States

Funder

National Institutes of Health

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.1c00880

Reference57 articles.

1. On the attribution and additivity of binding energies

2. Stromelysin Inhibitors Designed from Weakly Bound Fragments: Effects of Linking and Cooperativity

3. What is Cooperativity?

4. Velvadapu, V.; Farmer, B. T.; Reitz, A. B. Fragment-Based Drug Discovery; The Practice of Medicinal Chemistry, 2015; pp 161–180.

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