Identification, Characterization, and Synthesis of Natural Parasitic Cysteine Protease Inhibitors: Pentacitidins Are More Potent Falcitidin Analogues

Author:

Brinkmann Stephan1ORCID,Semmler Sandra1,Kersten Christian2ORCID,Patras Maria A.1,Kurz Michael3,Fuchs Natalie2ORCID,Hammerschmidt Stefan J.2,Legac Jenny4,Hammann Peter E.5,Vilcinskas Andreas16,Rosenthal Philip J.4,Schirmeister Tanja2,Bauer Armin3ORCID,Schäberle Till F.16ORCID

Affiliation:

1. Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch for Bioresources, Giessen 35392, Germany

2. Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University Mainz, Mainz 55128, Germany

3. Sanofi-Aventis Deutschland GmbH, R&D, Frankfurt am Main 65926, Germany

4. Department of Medicine, University of California, San Francisco, California 94143, United States

5. Evotec International GmbH, Göttingen 37079, Germany

6. Institute for Insect Biotechnology, Justus-Liebig-University of Giessen, Giessen 35392, Germany

Funder

Hessisches Ministerium f?r Wissenschaft und Kunst

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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