Unsymmetrically Regioselective Homodimerization Depends on the Subcellular Colocalization of Laccase/Fasciclin Protein in the Biosynthesis of Phlegmacins

Author:

Zhao Qunfei1ORCID,Zhuang Zheng1,Liu Tian2ORCID,Yang Qing34,He Qing-Li1,Liu Wen5ORCID,Lin Guo-Qiang16

Affiliation:

1. The Research Center of Chiral Drugs, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China

2. School of Bioengineering, Dalian University of Technology, No. 2 Linggong Road, Dalian 116024, China

3. Guangdong Laboratory for Lingnan Modern Agriculture (Shenzhen Branch), Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, No. 7 Pengfei Road, Shenzhen 518120, China

4. State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, No. 2 West Yuanmingyuan Road, Beijing 100193, China

5. State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China

6. CAS Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China

Funder

State Key Laboratory of Bio-organic and Natural Products Chemistry

Shanghai Municipal Education Commission

Shanghai Municipal Health Commission

National Natural Science Foundation of China

National Administration of Traditional Chinese Medicine

Shanghai Frontiers Science Center for Traditional Chinese Medicine Chemical Biology

Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs

Shenzhen Science and Technology Program

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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