Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion

Author:

Tollis Sylvain12ORCID,Rizzotto Andrea3,Pham Nhan T.4ORCID,Koivukoski Sonja1,Sivakumar Aishwarya3,Shave Steven4ORCID,Wildenhain Jan4,Zuleger Nikolaj3,Keys Jeremy T.5,Culley Jayne6,Zheng Yijing4,Lammerding Jan5,Carragher Neil O.6,Brunton Valerie G.6ORCID,Latonen Leena1,Auer Manfred4ORCID,Tyers Mike2ORCID,Schirmer Eric C.3

Affiliation:

1. Institute of Biomedicine, University of Eastern Finland, Kuopio 70210, Finland

2. Institute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec H3T 1J4, Canada

3. The Institute of Cell Biology, University of Edinburgh, Kings Buildings, Michael Swann Buildings, Max Born Crescent, Edinburgh EH9 3BF, U.K.

4. Institute of Quantitative Biology, Biochemistry and Biotechnology, University of Edinburgh, Edinburgh EH9 3BF, U.K.

5. Nancy E. and Peter C. Meinig School of Biomedical Engineering & Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York 14853, United States

6. Edinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, U.K.

Funder

Medical Research Council

Sigrid Jus?liuksen S??ti?

Institute of Genetics

Sy?p?j?rjest?t

Wellcome Trust

U.S. Department of Defense

Academy of Finland

Division of Chemical, Bioengineering, Environmental, and Transport Systems

Finnish Cancer Institute

National Institutes of Health

H2020 European Research Council

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

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