1. Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
2. Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
3. Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Oxford, United Kingdom
4. Department of Pharmacology, University of Oxford, Oxford, United Kingdom
5. Discovery Sciences, IMED Biotech Unit, AstraZeneca, Waltham, Massachusetts 02451, United States
6. Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden