A cell-permeable probe for the labelling of a bacterial glycosyltransferase and virulence factor-Reference-Cited by-同舟云学术

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A cell-permeable probe for the labelling of a bacterial glycosyltransferase and virulence factor

Published:2024 Issue:1 Volume:5 Page:55-62
ISSN:2633-0679
Container-title:RSC Chemical Biology
language:en
Short-container-title:RSC Chem. Biol.

Author:

Xu Yong¹,Wagner Gerd K.²^ORCID

Affiliation:

1. Department of Chemistry, King's College London, UK

2. School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK

Abstract

We report a chemical probe for the fluorescent labelling of the bacterial glycosyltransferase LgtC, a known virulence factor in Haemophilus and Neisseria species, and its application with recombinant protein, cell lysates, and intact cells.

Funder

King's College London

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Biochemistry, Genetics and Molecular Biology (miscellaneous),Molecular Biology,Biochemistry,Chemistry (miscellaneous)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/CB/D3CB00092C

Reference30 articles.

1. Emerging structural insights into glycosyltransferase-mediated synthesis of glycans

2. Glycosyltransferases: Structures, Functions, and Mechanisms

3. The Sweet Tooth of Bacteria: Common Themes in Bacterial Glycoconjugates

4. Y.Xu , N.Uddin and G. K.Wagner , Covalent Probes for Carbohydrate-Active Enzymes: From Glycosidases to Glycosyltransferases , in Methods in Enzymology , ed. B. Imperiali , Academic Press , 2018 , ch. 9, pp. 237–265

5. Generating orthogonal glycosyltransferase and nucleotide sugar pairs as next-generation glycobiology tools

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