Contribution of Noncovalent Recognition and Reactivity to the Optimization of Covalent Inhibitors: A Case Study on KRas<sup>G12C</sup>-Reference-Cited by-同舟云学术

Contribution of Noncovalent Recognition and Reactivity to the Optimization of Covalent Inhibitors: A Case Study on KRas^G12C

Published:2024-07-11 Issue:8 Volume:19 Page:1743-1756
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Péczka Nikolett¹²,Ranđelović Ivan³,Orgován Zoltán¹,Csorba Noémi¹²,Egyed Attila¹,Petri László¹,Ábrányi-Balogh Péter¹^ORCID,Gadanecz Márton⁴⁵^ORCID,Perczel András⁴,Tóvári József³^ORCID,Schlosser Gitta⁶^ORCID,Takács Tamás⁷⁸,Mihalovits Levente M.¹^ORCID,Ferenczy György G.¹,Buday László⁷^ORCID,Keserű György M.¹²^ORCID

Affiliation:

1. Medicinal Chemistry Research Group and National Drug Discovery and Development Laboratory, HUN-REN Research Centre for Natural Sciences, Budapest 1117, Hungary

2. Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, Budapest 1111, Hungary

3. Department of Experimental Pharmacology and the National Tumor Biology Laboratory, National Institute of Oncology, Budapest 1122, Hungary

4. Protein Modeling Research Group, Laboratory of Structural Chemistry and Biology, ELTE Institute of Chemistry, Budapest 1117, Hungary

5. Hevesy György PhD School of Chemistry, Eötvös Loránd University, Pázmány Péter sétány. 1/A, Budapest 1117, Hungary

6. MTA-ELTE “Lendület”, Ion Mobility Mass Spectrometry Research Group, Budapest 1117, Hungary

7. HUN-REN Research Centre for Natural Sciences, Signal Transduction and Functional Genomics Research Group, Budapest 1117, Hungary

8. Doctoral School of Biology, Institute of Biology, ELTE Eötvös Loránd University, Budapest 1117, Hungary

Funder

Nemzeti Kutat??si Fejleszt??si ??s Innov??ci??s Hivatal

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.4c00217

Reference63 articles.

1. Advances in covalent drug discovery

2. Emerging and Re-Emerging Warheads for Targeted Covalent Inhibitors: Applications in Medicinal Chemistry and Chemical Biology

3. Recent Advances in Covalent Drug Discovery

4. Evaluation of Enzyme Inhibitors in Drug Discovery

5. A Perspective on the Kinetics of Covalent and Irreversible Inhibition