Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as “Doorstop” for NADPH Entry-Reference-Cited by-同舟云学术

Fragment-Based Discovery of a Regulatory Site in Thioredoxin Glutathione Reductase Acting as “Doorstop” for NADPH Entry

Published:2018-05-25 Issue:8 Volume:13 Page:2190-2202
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Silvestri Ilaria¹,Lyu Haining²,Fata Francesca¹,Boumis Giovanna³,Miele Adriana E.³⁴,Ardini Matteo¹,Ippoliti Rodolfo¹^ORCID,Bellelli Andrea³,Jadhav Ajit⁵,Lea Wendy A.⁵,Simeonov Anton⁵,Cheng Qing⁶,Arnér Elias S. J.⁶^ORCID,Thatcher Gregory R. J.⁷^ORCID,Petukhov Pavel A.⁷^ORCID,Williams David L.²^ORCID,Angelucci Francesco¹

Affiliation:

1. Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy

2. Department of Microbial Pathogens and Immunity, Rush University Medical Center, Chicago, Illinois 60612, United States

3. Department of Biochemical Sciences, Sapienza University of Rome, 00185 Roma, Italy

4. UMR5246 ICBMS − CNRS − UCBL, Université de Lyon, 69007 Lyon, France

5. National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland 20892, United States

6. Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE-171 77 Stockholm, Sweden

7. Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60607, United States

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

National Institute of Allergy and Infectious Diseases

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.8b00349

Reference63 articles.

1. Trypanotliione reductase and lipoamide dehydrogenase as targets for a structure‐based drug design

2. Catalytic Cycle of Human Glutathione Reductase Near 1 Å Resolution