Biosynthesis of Largimycins in <i>Streptomyces argillaceus</i> Involves Transient β-Alkylation and Cryptic Halogenation Steps Unprecedented in the Leinamycin Family-Reference-Cited by-同舟云学术

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Biosynthesis of Largimycins in Streptomyces argillaceus Involves Transient β-Alkylation and Cryptic Halogenation Steps Unprecedented in the Leinamycin Family

Published:2022-07-13 Issue:8 Volume:17 Page:2320-2331
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Becerril Adriana¹²,Pérez-Victoria Ignacio³^ORCID,Martín Jesús M.³,Reyes Fernando³^ORCID,Salas Jose A.¹²,Méndez Carmen¹²^ORCID

Affiliation:

1. Departamento de Biología Funcional e Instituto Universitario de Oncología del Principado de Asturias (I.U.O.P.A), Universidad de Oviedo, 33006 Oviedo, Spain

2. Instituto de Investigación Sanitaria de Asturias (ISPA), 33011 Oviedo, Spain

3. Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Armilla, 18016 Granada, Spain

Funder

Ministerio de Asuntos Econ?micos y Transformaci?n Digital, Gobierno de Espa?a

Ministerio de Econom?a y Competitividad

Universidad de Oviedo

Gobierno del Principado de Asturias

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.2c00416

Reference39 articles.

1. The Biosynthetic Logic of Polyketide Diversity

2. Chapter 8 Type I Polyketide Synthases That Require Discrete Acyltransferases

3. Biosynthesis of polyketides by trans-AT polyketide synthases

4. Isoprenoid-like alkylations in polyketide biosynthesis

5. Polyketide β-branching: diversity, mechanism and selectivity

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