Polyketide β-branching: diversity, mechanism and selectivity-Reference-Cited by-同舟云学术

Polyketide β-branching: diversity, mechanism and selectivity

Published:2021 Issue:4 Volume:38 Page:723-756
ISSN:0265-0568
Container-title:Natural Product Reports
language:en
Short-container-title:Nat. Prod. Rep.

Author:

Walker P. D.¹²³⁴⁵^ORCID,Weir A. N. M.⁶⁷⁸⁵^ORCID,Willis C. L.⁶⁷⁸⁵^ORCID,Crump M. P.⁶⁷⁸⁵^ORCID

Affiliation:

1. Institute of Metabolism and Systems Research

2. College of Medical and Dental Sciences

3. University of Birmingham

4. Birmingham

5. UK

6. School of Chemistry

7. University of Bristol

8. Bristol

Abstract

The structural diversity of newly discovered polyketides continues to grow. This review summarises the range of structures with single and multiple β-branches and the mechanistic details of each catalytic step, covering literature from 2008 to August 2020.

Funder

Engineering and Physical Sciences Research Council

Cancer Research UK

Biotechnology and Biological Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/NP/D0NP00045K

Reference176 articles.

1. Biosynthesis of polyketides by trans-AT polyketide synthases