Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators-Reference-Cited by-同舟云学术

Mechanistic Impact of Different Ligand Scaffolds on FXR Modulation Suggests Avenues to Selective Modulators

Published:2022-11-01 Issue:11 Volume:17 Page:3159-3168
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Heering Jan¹^ORCID,Jores Nathalie²,Kilu Whitney³,Schallmayer Espen³,Peelen Evelyn⁴,Muehler Andreas⁴,Kohlhof Hella⁴,Vitt Daniel⁴,Linhard Verena²,Gande Santosh L.²,Chaikuad Apirat³^ORCID,Sreeramulu Sridhar²,Schwalbe Harald²^ORCID,Merk Daniel³⁵^ORCID

Affiliation:

1. Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, and Fraunhofer Cluster of Excellence for Immune Mediated Diseases CIMD, 60596Frankfurt, Germany

2. Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe-University Frankfurt, 60438Frankfurt, Germany

3. Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, 60438Frankfurt, Germany

4. Immunic AG, 82166Gräfelfing, Germany

5. Department of Pharmacy, Ludwig-Maximilians-Universität München, 81377Munich, Germany

Funder

DFG graduate college

Immunic AG

State of Hessen

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.2c00599

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4. The role of farnesoid X receptor in metabolic diseases, and gastrointestinal and liver cancer

5. Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease

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