When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal Antagonists-Reference-Cited by-同舟云学术

When Two Become One: Conformational Changes in FXR/RXR Heterodimers Bound to Steroidal Antagonists

Published:2022-11-30 Issue:4 Volume:18 Page:
ISSN:1860-7179
Container-title:ChemMedChem
language:en
Short-container-title:ChemMedChem

Author:

Díaz‐Holguín Alejandro¹²,Rashidian Azam³⁴,Pijnenburg Dirk⁵,Monteiro Ferreira Glaucio⁶,Stefela Alzbeta⁷,Kaspar Miroslav⁸⁹,Kudova Eva⁸,Poso Antti³⁴¹,van Beuningen Rinie⁵,Pavek Petr⁷,Kronenberger Thales³⁴¹^ORCID

Affiliation:

1. School of Pharmacy Faculty of Health Sciences University of Eastern Finland Kuopio 70211 Finland

2. Current address: Science for Life Laboratory Department of Cell and Molecular Biology Uppsala University 75124 Uppsala Sweden

3. Institute of Pharmacy Pharmaceutical/Medicinal Chemistry and Tübingen Center for Academic Drug Discovery & Development (TüCAD2) Eberhard Karls University Tübingen Auf der Morgenstelle 8 72076 Tübingen Germany

4. Department of Internal Medicine VIII University Hospital of Tübingen Otfried-Müller-Strasse 14 72076 Tübingen Germany

5. PamGene International B.V. Wolvenhoek 10 5211HH ‘s-Hertogenbosch Netherlands

6. Department of Clinical and Toxicological Analyses School of Pharmaceutical Sciences University of São Paulo Av. Prof. Lineu Prestes 580 05508-000 São Paulo Brazil

7. Department of Pharmacology and Toxicology Charles University Heyrovskeho 1203 50005 Hradec Kralove Czechia

8. Institute of Organic Chemistry and Biochemistry Czech Academy of Sciences Flemingovo náměstí 542/2 16000 Prague Czechia

9. Faculty of Sciences Charles University in Prague Albertov 6 Prague 2 12843 Czechia

Funder

Fundação de Amparo à Pesquisa do Estado de São Paulo

Akademie Věd České Republiky

Publisher

Wiley

Subject

Organic Chemistry,General Pharmacology, Toxicology and Pharmaceutics,Molecular Medicine,Drug Discovery,Biochemistry,Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/cmdc.202200556

Reference55 articles.

1. Bile acids and their receptors in metabolic disorders

2. Progress and challenges of selective Farnesoid X Receptor modulation

3. Update on FXR Biology: Promising Therapeutic Target?

4. Bile acids in glucose metabolism and insulin signalling — mechanisms and research needs

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